Catalog Number - 68504-SP-PG1-3

Cogent RP C4™ Wide Pore Semi-Prep Guard Column Cartridges are designed to protect valuable semi-preparative HPLC columns from particulates, strongly retained compounds, and sample contaminants that can reduce column performance and shorten column life. Packed with the same RP C4™ Wide Pore stationary phase used in Cogent semi-preparative columns, these guard cartridges help maintain method consistency while extending column service life. The stationary phase consists of a four-carbon butyl ligand bonded to ultra-high purity silica and is fully double end capped for reproducible reversed-phase performance.

68504-SP-PG1-3 is a semi-preparative guard column cartridge set packed with 5 µm RP C4™ Wide Pore particles featuring a 300 Å pore size in a 10 mm ID x 10 mm format. Designed specifically to protect RP C4™ Wide Pore semi-preparative columns, these cartridges capture particulates and contaminants before they reach the column bed. The 300 Å pore structure is ideal for protein, peptide, enzyme, and other biomolecule separations. Constructed from stainless steel tubing with stainless steel frits, they provide durability and reliable performance in demanding purification applications. This package contains five guard column cartridges.

Routine replacement of guard cartridges helps maintain column efficiency, preserve chromatographic performance, and reduce the cost of semi-preparative column replacement. These cartridges are particularly useful for biomolecule purification workflows in pharmaceutical, biopharmaceutical, and research laboratories.

Key Benefits

• RP C4™ Wide Pore stationary phase

• USP L26 equivalent chemistry

• Butyl (C4) bonded phase

• Fully double end capped

• Ultra-high purity silica support

• 300 Å wide pore design

• Protects semi-preparative columns from contamination

• Extends column lifetime

• Maintains chromatographic performance

• Supplied as a 5-pack

Typical Applications

• Semi-preparative HPLC

• Protein purification

• Peptide purification

• Enzyme purification

• Biomolecule isolation

• Fraction collection

• Biopharmaceutical analysis

• Method development

• Process development

• Semi-preparative column protection

Specifications

• Product Type: Semi-Preparative Guard Column Cartridge

• Stationary Phase: RP C4™ Wide Pore

• USP Classification: L26

• Chromatography Mode: Reversed Phase

• Bonded Phase: Butyl (C4)

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 300 Å

• Cartridge Dimensions: 10 mm ID x 10 mm

• Construction: Stainless Steel Tube with Stainless Steel Frits

• Quantity: 5/PK

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Designed to protect RP C4™ Wide Pore semi-preparative columns from particulates and contaminants

• 300 Å wide pores are ideal for proteins, peptides, enzymes, and other large biomolecules

• Helps extend column service life and maintain chromatographic performance

• Suitable for semi-preparative biomolecule purification applications

• Constructed with durable stainless steel hardware

• A specialized HPLC system capable of semi-preparative flow rates is recommended

• A Cogent 10 mm ID Semi-Prep Guard Column Holder (83000-SP-GH) is required for use with these guard column cartridges

• Supplied as a convenient 5-pack

• This is a Special Order Item